Microarray databases
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A microarray database is a repository containing microarray gene expression data. The key uses of a microarray database are to store the measurement data, manage a searchable index, and make the data available to other applications for analysis and interpretation (either directly, or via user downloads).
Microarray databases can fall into two distinct classes:
1. A peer reviewed, public repository that adheres to academic or industry standards and is designed to be used by many analysis applications and groups. A good example of this is the Gene Expression Omnibus (GEO) from NCBI or ArrayExpress from EBI.
2. A specialized repository associated primarily with the brand of a particular entity (lab, company, university, consortium, group), an application suite, a topic, or an analysis method, whether it is commercial, non-profit, or academic. These databases might have one or more of the following characteristics:
β’ A subscription or license may be needed to gain full access,
β’ The content may come primarily from a specific group (e.g. SMD, or UPSC-BASE), the Immunological Genome Project
β’ There may be constraints on who can use the data or for what purpose data can be used,
β’ Special permission may be required to submit new data, or there may be no obvious process at all,
β’ Only certain applications may be equipped to use the data, often also associated with the same entity (for example, caArray at NCI is specialized for the caBIG),
β’ Further processing or reformatting of the data may be required for standard applications or analysis,
β’ They claim to address the 'urgent need' to have a standard, centralized repository for microarray data. (See YMD, last updated in 2003, for example),
β’ There is a claim to an incremental improvement over one of the public repositories,
β’ A meta-analysis application, which incorporates studies from one or more public databases (e.g. Gemma primarily uses GEO studies; NextBio uses various sources)
Some of the most known public, curated microarray databases are:
| Database | Scope |
|---|---|
| ArrayTrack | ArrayTrack hosts both public and privat⦠|
| NCI mAdb | Hosts NCI data with integrated analysis⦠|
| ImmGen database | Open access across all immune system ce⦠|
| Genevestigator | Gene expression search engine based on⦠|
| Gene Expression Omnibus - NCBI | any curated MIAME compliant molecular a⦠|
| ArrayExpress at EBI | Any curated MIAME or MINSEQE compliant⦠|
| Stanford Microarray database | private and published microarray and mo⦠|
| The Cancer Genome Atlas (TCGA) | collection of expression data for diffe⦠|
| GeneNetwork system | Open access standard arrays, exons arra⦠|
| UNC modENCODE Microarray database | Nimblegen customer 2.1 million array |
| UPSC-BASE | data generated by microarray analysis w⦠|
| UPenn RAD database | MIAME compliant public and private stud⦠|
| UNC Microarray database | provides the service for microarray dat⦠|
| MUSC database | The database is a repository for DNA mi⦠|
| caArray at NCI | Cancer data, prepared for analysis on c⦠|
| Database | Microarray experiment sets | Sample profiles |
|---|---|---|
| ArrayTrack | 1622 | 50,093 |
| NCI mAdb | ? | 105,000 |
| ImmGen database | 267 | 1059 |
| Genevestigator | 3228 | 232,855 |
| Gene Expression Omnibus - NCBI | 25859 | 641770 |
| ArrayExpress at EBI | 24838 | 708914 |
| Stanford Microarray database | 82542 | ? |
| The Cancer Genome Atlas (TCGA) | 21229 | ? |
| GeneNetwork system | ~100 | ~10000 |
| UNC modENCODE Microarray database | ~6 | 180 |
| UPSC-BASE | ~100 | ? |
| UPenn RAD database | ~100 | ~2500 |
| UNC Microarray database | ~31 | 2093 |
| MUSC database | ~45 | 555 |
| caArray at NCI | 41 | 1741 |
| Database | As of date |
|---|---|
| ArrayTrack | Feb 2012 |
| NCI mAdb | Mar 2012 |
| ImmGen database | Jan 2012 |
| Genevestigator | October 2016 |
| Gene Expression Omnibus - NCBI | October 28, 2011 |
| ArrayExpress at EBI | October 28, 2011 |
| Stanford Microarray database | October 23, 2011 |
| The Cancer Genome Atlas (TCGA) | August 30, 2013 |
| GeneNetwork system | July, 2010 |
| UNC modENCODE Microarray database | July 17, 2009 |
| UPSC-BASE | November 15, 2007 |
| UPenn RAD database | Sept. 1, 2007 |
| UNC Microarray database | April 1, 2007 |
| MUSC database | April 1, 2007 |
| caArray at NCI | November 15, 2006 |
Contents
β’ See also
β’ External links
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See also
External links
β’ ArrayExpress: Quick Tour on EBI Train OnLine
β’ Exploring functional genomics data with the ArrayExpress Archive on EBI Train OnLine
β’ Investigating gene expression patterns with the Gene Expression Atlas on EBI Train OnLine
β’ ArrayExpress:Submitting data using MAGE-TAB on EBI Train OnLine
β’ ArrayExplorer - A free tool to compare microarrays side by side.